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M94A3146.TXT
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1994-10-25
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Document 3146
DOCN M94A3146
TI Interaction of HIV and human herpesvirus 7 in a CD4+ T cell line.
DT 9412
AU Yamada M; Kamiya T; Yoshida M; Matsuo Y; Ikuta K; Yamanishi K; Okuno T;
Minowada J; Nii S; Dep. of Virol., Okayama Univ. Med. Sch., Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):142 (abstract no. PA0186). Unique
Identifier : AIDSLINE ICA10/94369429
AB OBJECTIVE: Human Herpesvirus 7 (HHV-7), a new T-lymphotropic
herpesvirus, is related to, but significantly different from HHV-6.
HIV-1 and HHV-7, as well as HHV-6, are believed to share CD4+ T
lymphocytes as major target cells, and, for this reason, we studied the
interaction of HIV-1 and HHV-7 using a CD4+ T cell line. METHODS: A CD4+
CD8+ cell line, SUP-T1, and a HIV carrier cell line established from
SUP-T1 were tested for permissiveness to HHV-6 or HHV-7 replication.
RESULTS: The SUP-T1 is to date the only cell line, among 10 CD4+ T cell
lines, susceptible to the productive infection of HHV-7. Expression of
the CD4 antigen was completely downregulated in the HIV-1 carrier cell
line. While superinfection of HIV-1 carrier SUP-T1 cells with HHV-6 was
readily accomplished, the same cells were completely resistant to
superinfection with HHV7. Furthermore, treatment of SUP-T1 cells with
anti-CD4 monoclonal antibodies inhibited the growth of HHV-7. On the
other hand, HHV-7 carrier SUP-T1 cells were readily superinfected with
HIV-1. DISCUSSION AND CONCLUSIONS: Resistance of HIV-1 carrier SUP-T1
cells to HHV-7 is due to the absence of the CD4 antigen on the cell
surface. HIV-1 and HHV-7 are supposed to use the same molecule, the CD4
antigen, as the virus receptor.
DE Antigens, CD/*PHYSIOLOGY Antigens, CD4/PHYSIOLOGY Antigens,
CD8/PHYSIOLOGY Cell Line Comparative Study Herpesvirus 6,
Human/*PHYSIOLOGY Herpesvirus 7, Human/*PHYSIOLOGY Human
HIV-1/*PHYSIOLOGY Superinfection
T-Lymphocytes/IMMUNOLOGY/*MICROBIOLOGY T4
Lymphocytes/IMMUNOLOGY/*MICROBIOLOGY *Virus Replication MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).